Moringa oleifera extract and neostigmine confer neuroprotection on aluminium chloride -induced Alzheimer’s disease: Antioxidant and acetylcholinesterase inhibitory activities

Alzheimer’s disease (AD) is a neurological episode associated with the senescence process characterized by neuronal cell death in brain regions and loss of cognition. The study investigate neuroprotective potentials Moringa oleifera leaf extract Neostigmine rat model induced Aluminium chloride (AlCl3). A total number 20 rats weighing 180-240 kg were used for this they grouped into 5 4 each group (n=4) labelled A-E. Group control, received 0.1 mL normal saline (placebo), B, 100 mg/kg chloride, C was given 200 mg/kg, D experimental animals treated 400 orally 21 days, while E same dose Alcl3 2 intraperitoneal (IP). Thereafter, sacrificed, hippocampi harvested histology histochemical analysis. Our findings revealed visible protective changes M. as pyramidal cells CA3 neurofibrillary tangles which prominent positive control resolved. At end study, it proven that toxicity reduced Neostigmine. commonly consumed plant therefore intake should be encouraged.